In this study, physicians from Japan investigated whether family history had an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection.
They evaluated 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC study).
The team found that a positive history of stomach cancer in 1 or more first-degree relatives was associated with an increased risk of the disease in women, but not in men.
|Family history was associated with an increased risk in women, but not in men.|
|British Journal of Cancer|
This pattern remained after controlling for H. pylori infection and other confounding variables.
The physicians found that women with both a family history and H. pylori infection had more than a 5-fold increased risk of the disease (OR 5.10).
Dr Yatsuya and colleagues concluded, "These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone".