In this study, doctors from Pittsburgh, Pennsylvania, evaluated the clinical course and outcome of patients with graft versus host disease after intestinal transplantation.
They retrospectively reviewed 250 patients who received an intestinal transplantation between 1990 and 2003.
Graft versus host disease was suspected in 23 patients.
The team found that 14 patients had graft versus host disease confirmed by histopathological criteria.
|Most cases were resolved with steroid administration and immunosuppression optimization.|
|American Journal of Transplantation|
The team identified donor-cell tissue infiltration or extensive peripheral blood donor-cell chimerism in 7 patients.
The doctors determined that the majority of cases were resolved with steroid administration and optimization of tacrolimus immunosuppression.
Dr George Mazariegos and colleagues concluded, "The incidence of histologically proven graft versus host disease after clinical intestinal transplantation is 6.5% (8/122) in children and 4.7% (6/128) in adults".
"Successful clinical management requires a high index of suspicion to minimize morbidity and mortality".
"Diagnostic and treatment strategies based on this experience are proposed".