Non-steroidal anti-inflammatory drugs have been implicated in reports of liver injury.
In this study, researchers from the United States performed a systematic review of studies reporting the incidence or risk of non-steroidal anti-inflammatory drugs for liver injury.
The team identified 7 studies which met their inclusion criteria.
|There were no deaths from liver injury associated with NSAIDs.|
|Alimentary Pharmacology and Therapeutics|
They found that the comparative risk of liver injury resulting in hospitalization for current users compared with past users ranged from 1.2 to 1.7. This was not statistically significant.
They calculated that the incidence of liver injury resulting in hospitalization ranged from 3.1 to 23.4/100,000 patient-years of current use of non-steroidal anti-inflammatory drugs.
When compared with past users, there was an excess risk of 4.8 to 8.6/100,000 patient-years of exposure.
The researchers determined that there were no deaths from liver injury associated with non-steroidal anti-inflammatory drugs use in over 396,392 patient-years of cumulative exposure.
Drs Rubenstein and Laine concluded, "These findings allow for the possibility of a small increase in the risk of clinically relevant hepatotoxicity with non-steroidal anti-inflammatory drugs use, but do not document that such a risk occurs".