Studies of acute liver failure from drugs report limited data on drugs other than acetaminophen.
In this study, physicians from the United States identified liver recipients and estimated the rate of liver transplantation due to acute liver failure from drugs.
They team used data from the United Network for Organ Sharing (UNOS) liver transplant database from 1990 to 2002.
Patients were identified if their diagnosis was acute hepatic necrosis from an implicated drug at the time of transplant.
The physicians found that liver transplantation for drug hepatotoxicity accounted for 15% of liver transplants for acute liver failure during the study period.
The team found that in the cohort of 206 recipients, 76% we female.
They found that acetaminophen alone, or in combination with another drug, accounted for 49% of cases.
In the non-acetaminophen group, the most frequently implicated drugs were isoniazid (18%), propylthiouracil (10%), phenytoin (7%), and valproate (7%).
In the acetaminophen only group 53% of patients were Caucasian and 25% were African-American. However, in the non-acetaminophen group 47% of patients were Caucasian and 75% were African-American.
The team found that 78% of African-Americans in the non-acetaminophen group were women.
Dr Mark Russo's team concluded, "4 drugs were implicated in 42% of patients undergoing liver transplantation for acute liver failure due to drugs other than acetaminophen".
"The increased frequency of African-American women undergoing liver transplantation for non-acetaminophen drug induced liver injury warrants further study".