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News

Immunochromatographic sticks for screening in celiac disease

Visual assays are efficient alternatives to ELISAs for celiac disease screening, find researchers in the June issue of Clinical Gastroenterology and Hepatology.

News image

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In this study, a team of researchers from Spain evaluated 2 immunochromatographic visual assays as an alternative to enzyme-linked immunosorbent assays (ELISAs) for celiac disease screening.

The team used a tissue-transglutaminase stick to detect immunoglobulin A/G (IgA/G) antibodies to t-TG, and a t-TG/antigliadin antibodies (AGA) stick to detect IgA antibodies to both t-TG and AGA. They also used t-TG and AGA ELISAs.

Overall, the team assayed a total of 142 children and 30 adults, and 140 controls. They also assayed 23 sera from pediatric celiac patients in remission.
Results were comparable with the corresponding ELISAs.
Clinical Gastroenterology and Hepatology

The researchers found that the t-TG stick had a sensitivity of 97% and a specificity of 99% in pediatric patients; sensitivity was 83% and specificity 100% in adults.

In addition, they found that the t-TG/AGA stick had a sensitivity of 96% and a specificity of 99% for t-TG and a sensitivity of 89% and a specificity of 96% for AGA in children.

In adults, sensitivity was 80% and specificity 100% for t-TG, while sensitivity was 83% and specificity of 100% for AGA.

The research team found that results were comparable with the corresponding ELISAs.

Dr Sergio Ferre-lópez's team concluded, "The 2 visual assays are efficient for celiac disease screening as an alternative to ELISAs".

"They are simple to handle and to interpret".

"By the combined use of the 2 sticks, IgA-deficient patients can be identified as positive in the t-TG (IgG/A) but negative in the t-TG/AGA (IgA) stick".

Clinical Gastroenterology and Hepatology 2004; 2(6):
08 June 2004

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