The association of celiac disease and type 1 diabetes is now clearly documented.
In this study, researchers from Canada and France measured immunoglobulin A (IgA) antitransglutaminase antibodies to determine the prevalence of celiac disease in 284 diabetic children.
They also determined the temporal relationship between type 1 diabetes onset and celiac disease.
The team measured the antibodies using human recombinant antigen in parallel with IgA and IgG antigliadin, and IgA antiendomysium.
|The prevalence of celiac disease was 4%.|
The researchers found that the prevalence of celiac disease was 4%.
Two cases of celiac disease were diagnosed before the onset of diabetes.
In a further 8 children, the diagnoses of celiac disease and diabetes were concomitant. This suggests that celiac disease was present before the onset of diabetes.
In addition, a child who presented with thyroiditis had serology for celiac disease become positive after diabetes had been diagnosed.
Dr Noel Peretti and colleagues concluded, "An excellent correlation was observed between IgA antiendomysium and IgA antitransglutaminase antibodies".
"We therefore propose using IgA antitransglutaminase as a screening test for practical reasons".
"Furthermore, IgA antitransglutaminase levels and mucosa abnormalities were closely correlated".
"The presence of antitransglutaminase antibodies should alert pediatricians to the atypical forms of celiac disease".
"This study indicates that celiac disease is most often present before the onset of diabetes".