Treatment of celiac disease (CD) requires adherence to a strict gluten free diet (GFD).
However, recent studies have shown that oats are non-toxic to CD patients.
|All patients were in clinical remission at the end of the study.|
In this study, doctors from Sweden determined whether children with CD tolerate oats in their GFD.
The team conducted a double blind multicenter study involving 8 pediatric clinics.
They randomized 116 children with newly diagnosed CD to 1 of 2 groups. The first group was given a standard GFD (GFD-std), while the second group was given a GFD with additional wheat free oat products (GFD-oats).
The study period was 1 year.
The team performed a small bowel biopsy was performed at the beginning and end of the study.
In addition, they monitored serum IgA antigliadin, antiendomysium, and antitissue transglutaminase antibodies at 0, 3, 6, and 12 months.
Overall, 93 patients completed the study.
The team found that the median daily oat intake in the GFD-oats group was 15g.
They found that all patients were in clinical remission at the end of the study.
The doctors determined that serology markers and small bowel architecture did not differ between the 2 groups at the end of the study.
Dr Högberg and colleagues concluded, "The addition of moderate amounts of oats to a GFD does not prevent clinical or small bowel mucosal healing, or humoral immunological downregulation in celiac children".
"This is in accordance with the findings of studies in adult celiacs and indicates that oats, added to the otherwise GFD, can be accepted and tolerated by the majority of children with CD".