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 24 February 2018

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News

Effect of maternal antibody on immunogenicity of hepatitis A vaccine in infants

Passively acquired maternal anti-hepatitis A virus results in a lower final antibody response, find researchers in the March issue if the Journal of Pediatrics.

News image

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In this study researchers from the United States determined the effect of maternal antibody on hepatitis A vaccine immunogenicity in infants.

The team administered hepatitis A vaccine to the infants of mothers negative for antibody to hepatitis A virus (anti-HAV) 2, 4, and 6 months of age.

In addition, the infants of anti-HAV–positive mothers were randomized to receive either hepatitis A vaccine (group 2) or hepatitis B vaccine (group 3). Infants in group 3 received hepatitis A vaccine at 8 and 10 months of age.
100% of infants in group 1, 93% in group 2, and 92% in group 3 had protective levels of antibody.
Journal of Pediatrics

The researchers found that at 15 months of age, 100% of infants in group 1, 93% in group 2, and 92% in group 3 had protective levels of antibody.

However, the team identified significant differences in the geometric mean concentration (GMC) of anti-HAV between groups:

  • Group 1 = 231 mIU/mL
  • Group 2 = 85 mIU/mL
  • Group 3 = 84 mIU/mL.

Dr William Letson and colleagues concluded, "Passively acquired maternal anti-HAV resulted in a significantly lower final antibody response."

J Pediatrics 2004; 144(3):
12 March 2004

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