In this study, investigators from Mexico analyzed the clinicopathologic characteristics of young patients with gastric cancer.
The team paid special attention to hereditary gastric cancer in a tertiary referral university hospital.
The team reviewed the charts of 83 patients with diagnosed with gastric cancer between 1987 and 2001. Patients were under 40 years of age or younger (mean age = 33.2 years).
The team noted demographic variables, family history of gastric cancer, clinicopathologic characteristics, and treatment-related variables.
They measured overall survival as the main outcome variable.
Of the 83 patients, 17% had a family history of gastric cancer, and 6% fulfilled the criteria for hereditary gastric cancer.
|17% of patients had a family history of gastric cancer.|
|Journal of Gastrointestinal Surgery|
Surgery was performed in 88% of patients, but only 35% of the operations had a curative intent. Operative mortality was 2%.
Multivariate analysis showed that advanced tumor stage, pangastric tumor location, and absence of adjuvant chemotherapy were associated with poor prognosis.
However, family history of gastric cancer or hereditary gastric cancer did not have any impact on prognosis.
Dr Antonio Ramos-De la Medina's team concluded, "There is a high frequency of gastric cancer in young patients at our institution".
"Most patients present in advanced stages, which favors a poor overall survival".
"Family history of gastric cancer or hereditary gastric cancer did not have a significant impact on survival".
"Complete resection and adjuvant chemotherapy appeared to confer the only chance of prolonged survival".