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 28 May 2018

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News

Liver regeneration after split-liver transplantation

Liver regeneration is greatest in split-liver transplants recipients, find investigators in the latest issue of Liver Transplantation.

News image

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The number of living donor and deceased donor split-liver transplants have increased over the last 5 years.

In this study, investigators from the United States measured differences in liver regeneration between living donors, right-lobe living donor recipients, and split-liver transplants recipients.

The team measured liver volume at 3 months postoperatively by using by computed tomography (CT) volumetrics.

They compared the result to the patient's ideal liver volume (ILV), which was calculated using a standard equation.

Overall the team evaluated 70 adult patients who either had donated their right lobe for living donor transplants or undergone a partial-liver transplant.
Living donors showed a 1.85-fold increase in liver volume.
Liver Transplantation

The team found that the deceased donors were younger than the living donors, were heavier, and had longer ischemic times.

At 3 months postoperatively, they found that living donors had attained 79% of their ILV.

However, they determined that right-lobe living donor recipients had attained 104% of their ILV, right-lobe split-liver transplants recipients 114%, and left-lobe split-liver recipients 120%.

When liver size 3 months postoperatively was compared with liver size immediately postoperatively, living donors showed a 1.85-fold increase.

However, the increase seen in right-lobe living donor recipients, right-lobe split-liver transplants recipients, and left-lobe split-liver transplants recipients was 2.08-fold, 2.17-fold, and 2.52-fold, respectively.

Dr Abhinav Humar and colleagues concluded, "Liver regeneration…seems to be greatest in split-liver transplants recipients".

"Living donor recipients seem to have greater liver growth than their donors".

"The reason for this remains unclear".

Liver Transpl 2004; 10: 374-8
11 March 2004

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