Nonalcoholic fatty liver disease (NAFLD) is common in patients with type 2 diabetes mellitus (DM). It has been suggested as a risk factor for the development of nonalcoholic steatohepatitis.
In this study, physicians from the United States assessed the outcome of 132 patients with NAFLD and DM.
|33% of patients had diabetes mellitus.|
|Clinical Gastroenterology and Hepatology|
The team categorized and compared patients with NAFLD according to the presence or absence of DM.
The physicians found that 33% of patients had DM. These patients were older, had higher serum glucose and triglyceride levels, and a greater aspartate aminotransferase-alanine aminotransferase ratio.
The team found that liver biopsy specimens from patients with DM showed more vacuolated nuclei and acidophilic bodies.
They established that 25% of patients with DM had cirrhosis, compared to 10% of patients without DM.
The team also determined that overall mortality (risk ratio [RR] 3.30) and mortality related to liver disease (RR 22.83) were greater in the diabetic patients.
They also found that markers of hepatic dysfunction were the only independent predictors of increased mortality.
Dr Zobair Younossi's team concluded, "Patients with NAFLD and DM are at risk for the development of an aggressive outcome, such as cirrhosis and mortality".
"This study supports the potential role of insulin resistance in the development of poor clinical outcomes in patients with NAFLD".