Epidemiological studies suggest an association between diabetes mellitus (DM) and chronic hepatitis C virus (HCV) infection.
Both of these conditions are common in liver transplant recipients.
In this study, doctors from San Francisco, California, evaluated a cohort of 555 liver transplant recipients without preexisting diabetes. Patients were from 3 US centers.
The team followed patients for a median of 5 years
|De novo diabetes developed in 38% of patients.|
They defined de novo diabetes by the use of antidiabetic medications.
The team found that de novo diabetes developed in 38% of patients.
Of these, 28% had transient-DM (T-DM) and 9% had persistent-DM (P-DM).
The doctors found that in the HCV-infected transplant recipients, de novo T-DM and P-DM developed in 26% and 14%, respectively.
They established that HCV was predictive of P-DM but not of T-DM.
The team also found that older age and tacrolimus use were independent predictors of P-DM.
Dr Mandana Khalili's team concluded, "De novo diabetes is common in transplant recipients, but is typically transient in nature".
"However, among those developing de novo persistent diabetes, HCV is one of the most important risk factors".
"This adds further support to the epidemiological data linking HCV and diabetes".