In this study, doctors from Hong Kong, China, investigated the effect of the antispasmodic hyoscine N-butyl bromide (Buscopan) during colonoscopy.
The team assessed 120 patients undergoing colonoscopy. Patients were randomized to receive either 40 mg of hyoscine N-butyl bromide or saline solution intravenously as premedication.
|Fewer patients in the hyosine N-butyl bromide group were willing to repeat the procedure.|
Colonoscopy was performed under patient-controlled sedation.
The team evaluated intubation and procedure time, patient-controlled sedation, spasm score, pain score, endoscopist satisfaction score, patient willingness to repeat colonoscopy, and vital signs.
The doctors determined that mean cecal intubation time in the hyoscine N-butyl bromide group was longer than the control group (12.20 versus 9.74 minutes).
In addition, hyoscine N-butyl bromide was associated with a lower endoscopist mean satisfaction score, higher mean doses of patient-controlled sedation, and greater hemodynamic instability.
They also found that fewer patients in the hyoscine N-butyl bromide group were willing to repeat the procedure.
Dr Lik-man Mui's team concluded, "Premedication with intravenously administered hyoscine N-butyl bromide impedes colonoscope insertion and causes greater patient discomfort, as well as hemodynamic instability".