In this study, physicians from Sweden evaluated the symptoms and signs of celiac disease in children. They assessed whether the clinical picture at disease onset has changed in the last 10 years.
The team recorded all children with celiac disease from 8 pediatric departments in Southeast Sweden. Their symptoms were registered on a standard form.
|Clinical features of celiac disease have changed over the last 10 years.|
|Journal of Pediatric Gastroenterology and Nutrition|
The physicians gathered data from 79 children with biopsy-confirmed celiac disease, as well as 43 contemporary controls and 65 historic controls.
The team found that, compared to the controls, children with celiac disease had abdominal distension (odds ratio (OR) 22.17), thin extremities (OR 5.89), irritability (OR 6.50), and tiredness (OR 15.43).
When compared with the historical controls, the children in this study experienced diarrhea (OR 0.23), suboptimal weight gain (OR 0.02), and suboptimal linear growth (OR 0.14) less frequently.
Dr Ludvigsson's team concluded, "This study indicates that, in parallel to changes in incidence, clinical features of celiac disease in young children have changed during the last 10 years".