Weight gain has been repeatedly observed in cirrhotic patients following portosystemic shunting.
In this study, researchers from Germany examined the changes in body composition and energy metabolism associated with this procedure.
The team prospectively evaluated 21 patients before and 6 and 12 months after transjugular intrahepatic portosystemic shunt (TIPS).
They assessed patients' body cell mass using 2 separate methods:
- Total body potassium counting (BCMTBP).
- Bioelectric impedance analysis (BCMBIA).
They also assessed muscle mass, resting energy expenditure, and nutritional intake.
The researchers determined that the TIPS patients were hypermetabolic and their body cell mass was lower.
|. TIPS patients were hypermetabolic.|
|Journal of Hepatology|
Following TIPS body cell mass (BCMBIA) increased to 23.5 and 25.7 kg at 6 and 12 months, respectively. This increase was confirmed by total potassium counting (BCMTBP).
The researchers found that hypermetabolism persisted throughout the study period.
They also determined that energy intake increased by 26% and protein intake by 33%.
Dr Mathias Plauth's team concluded, "An increase of prognostically relevant variables body cell and muscle mass contributes to the weight gain after TIPS in malnourished patients with cirrhosis and hypermetabolism".