Small bowel adenocarcinoma is an uncommon complication of Crohn's disease.
In this study, doctors from the United States described the clinical features, outcomes, and risk factors of small bowel adenocarcinoma in Crohn's disease.
The team identified all patients with Crohn's disease and small bowel adenocarcinoma evaluated at their institution between 1976 and 2000.
The team also selected 2 matched controls with Crohn's disease for each case.
|In 89% of patients the cancer was located in the ileum.|
|Inflammatory Bowel Diseases|
Overall, the team identified 9 cases.
The patients presented with abdominal pain (89%), obstruction (89%), and weight loss (78%).
The team determined that the cancer was located in the ileum in majority of the patients (89%).
All cases but 1 had either lymph node involvement or metastasis.
All cases had surgery, with 1 receiving adjuvant chemotherapy.
The team was unable to identify any significant risk factors.
The calculated mortality rates at 1 and 2 years as 42% and 61%, respectively.
Dr Craig Solem's team concluded, "Small bowel adenocarcinoma is a rare complication of Crohn's disease that typically involves the ileum".
"Affected patients have symptomatic, advanced malignancies upon diagnosis".
"No significant risk factors were identified".