Flexible sigmoidoscopy is recommended for persons at average risk for colorectal cancer.
Follow-up is advised in 3 to 5 years. However, outcomes are not well established.
In this study, Dr Williamson Strum evaluated the incidence of advanced adenomas at flexible sigmoidoscopy 3 and 5 years after an initial negative examination.
He assessed 8121 patients referred for flexible sigmoidoscopy. Of these 4010 met the inclusion criteria.
|Family history of sporadic colorectal cancer did not alter incidence rates.|
|Digestive Diseases and Sciences|
Adenomas were considered advanced if they were villous, tubulovillous, high-grade dysplasia, adenocarcinoma, or ≥10 mm in size.
Patients received either a flexible sigmoidoscopy between 3 and 4 years (group 1), or between 5 and 6 years (group 2) after a negative examination.
Dr Strum found that the incidence rate for advanced adenomas was 0.9% in group 1, and 1.1% in group 2.
When the 2 groups were subdivided by family history of sporadic colorectal cancer, the incidence rates between the populations were not different.
Dr Strum concluded, "Our data indicate incidence rates of 0.9 and 1.1% for advanced adenomas at flexible sigmoidoscopy 3 and 5 years, respectively, after a negative flexible sigmoidoscopy".