Crohn's disease is thought to be caused by environmental factors in genetically susceptible individuals.
Mutations in CARD15, a gene involved in innate immunity, are known to predispose people to the disease.
|Refrigeration may be a risk factor for Crohn's disease.|
Bacteria that can survive in refrigerated food may be implicated in Crohn's disease.
Dr Jean-Pierre Hugot from Hopital Robert Debre, Paris, France, and colleagues discuss whether the production and storage of food in low temperatures is a potential major risk factor for Crohn's disease.
Dr Hugot comments, "All findings point to refrigeration as a potential risk factor for Crohn's disease".
"Furthermore, cold-chain development paralleled the outbreak of Crohn's disease during the 20th century".
"The cold-chain hypothesis suggests that psychrotrophic bacteria such as Yersinia and Listeria…contribute to the disease".
"These bacteria have been identified in Crohn's disease lesions".
"From a molecular perspective, we suggest that the disease is a result of a defect in host recognition by pathogenic bacterial components that usually escape the immune response, which results in an excessive host response to these bacteria."