Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 20 February 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Risks for advanced colonic neoplasia and hyperplastic polyps

Physicians in this week's issue of the Journal of the American Medical Association identify risk factors for advanced colonic neoplasia in asymptomatic individuals.

News image

fiogf49gjkf04

Identification of the risk factors for colorectal neoplasia may help in risk reduction. In this study, physicians from the United States determined the risk factors associated with advanced colorectal neoplasia in a cohort of asymptomatic individuals.

The team recruited 3121 asymptomatic patients (aged 50 to 75 years) from 13 medical centers.
Family history, smoking, and alcohol use are risk factors associated with advanced neoplasia.
Journal of the American Medical Association

All participants underwent complete colonoscopy to determine the prevalence of advanced neoplasia. This was defined as an adenoma that was ≥10 mm, a villous adenoma, an adenoma with high-grade dysplasia, or invasive cancer.

The physicians collected data on history of first-degree relative with colorectal cancer, prior cholecystectomy, serum cholesterol level, physical activity, smoking, alcohol use, and dietary factors.

They performed an age-adjusted analysis to calculate the odds ratios (ORs) of having advanced neoplasia, compared with having no polyps.

They also developed a multivariate logistic regression model to identify the most informative risk factors.

A secondary analysis examined risk factors for having hyperplastic polyps, compared with having no polyps, and compared with having advanced neoplasia.

The physicians found that 329 participants had advanced neoplasia, while 1441 had no polyps.

They identified that a first-degree relative with colorectal cancer (OR, 1.66), current smoking (OR, 1.85), and current moderate to heavy alcohol use (OR, 1.02) as risk factors associated with advanced neoplasia.

However, cereal fiber intake (OR, 0.95), vitamin D intake (OR, 0.94), and use of nonsteroidal anti-inflammatory drugs (NSAIDs) (OR, 0.66) were inversely associated.

Marginal factors included physical activity, daily multivitamin use, and intake of calcium and fat derived from red meat.

The team did not identify any association for body mass index, prior cholecystectomy, or serum cholesterol level.

In addition, 391 patients had hyperplastic polyps found at colonoscopy.

Risk variables were similar to those for patients with no polyps.

Dr David Lieberman's team concluded, "Our data endorse several important risk factors for advanced colonic neoplasia and provide a rationale for prudent risk reduction strategies".

"Further study is needed to determine if lifestyle changes can moderate the risk of colorectal cancer".

JAMA 2003; 290: 2959-67
11 December 2003

Go to top of page Email this page Email this page to a colleague

 20 February 2018 
Complications and surveillance colonoscopies
 20 February 2018 
Treatment algorithm for polyp cancers
 20 February 2018 
Predictors of postoperative infection in Crohn's
 19 February 2018 
Screening colonoscopy in the right and left colon
 19 February 2018 
NAFLD prevalence in the USA
 19 February 2018 
Fructans in children with IBS

 16 February 2018 
Undetected celiac in the elderly
 16 February 2018 
Inflammatory bowel diseases are global diseases
 16 February 2018 
Fructans induce non-celiac gluten sensitivity
 15 February 2018 
Oral direct-acting antiviral treatment for Hep C virus genotype 1
 15 February 2018 
NSAIDS and GI damage
 15 February 2018 
Primary vs secondary surgery for the presence of lymph node metastasis
 14 February 2018 
Management of hemorrhoids in the USA
 14 February 2018 
Predicting adenoma detection rate
 14 February 2018 
Normal bowel frequency characterization in the USA 
 13 February 2018 
Prebiotics improve endothelial dysfunction
 13 February 2018 
Personalising treatment options for IBS
 13 February 2018 
Diagnostic criteria for a Rome IV functional gastrointestinal disorders
 12 February 2018 
Visceral hypersensitivity and functional GI disorders
 12 February 2018 
Depression and aggressive IBD
 12 February 2018 
Variability in interpretation of endoscopic findings impacts patient management
 09 February 2018 
Treatment of choice for anastomotic stricture in IBD
 09 February 2018 
PRO measurement information system 
 09 February 2018 
Overall disease severity indices for IBD
 08 February 2018 
Prediction of endoscopically active disease

 08 February 2018 
Steroid-refractory acute severe ulcerative colitis
 08 February 2018 
Decision aid used by IBD patients
 07 February 2018 
Ursodeoxycholic acid combined with bezafibrate for itching
 07 February 2018 
Change in microbiome in gastritis vs gastric carcinoma
 07 February 2018 
Colorectal cancer and primary sclerosing cholangitis-IBD
 06 February 2018 
Risk of death after liver transplantation
 06 February 2018 
Crohn’s disease vs refractory pouchitis
 06 February 2018 
Support for functional dyspepsia symptom diary
 05 February 2018 
Helicobacter spp influence on GI tract 
 05 February 2018 
No link found between severe reflux and all-cause mortality 
 05 February 2018 
Psychological distress in PPI non-responders
 02 February 2018 
Assessing psychosexual impact of IBD
 02 February 2018 
Decrease in overall mortality with cholera vaccination
 02 February 2018 
Diagnostic performance of fecal immunochemical tests
 01 February 2018 
Screening frequency with family histories of colorectal cancer
 01 February 2018 
IBD and sport participation
 01 February 2018 
Life with a stoma 
 31 January 2018 
Aprepitant and gastroparesis 
 31 January 2018 
Anesthesia risk in colonoscopy
 31 January 2018 
GED-0301 for Crohn's Disease
 30 January 2018 
Intestinal dysbiosis and allergic diseases in infants
 30 January 2018 
Fructans and IBS symptoms in children
 29 January 2018 
Dosing calculator for therapy optimization in IBD
 29 January 2018 
Glecaprevir–pibrentasvir for in HCV
 29 January 2018 
Food allergen injections in eosinophilic esophagitis
 29 January 2018 
Reliability of the IBD index
 26 January 2018 
Tofacitinib vs biological therapies for ulcerative colitis
 26 January 2018 
Optimizing selection of biologics in IBD
 26 January 2018 
Nutritional risk and laparoscopic-assisted gastrectomy outcomes
 25 January 2018 
Patient-reported outcome measure for functional dyspepsia
 25 January 2018 
Predicting intra-abdominal infections after colorectal surgery
 25 January 2018 
Predictors of gastric cancer risk
 24 January 2018 
Risk factors underlying previously undiagnosed cirrhosis
 24 January 2018 
Ethnicity influences phenotype in IBD
 24 January 2018 
Bariatric surgery vs medical obesity treatment

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us