In this study, researchers from Spain and the United States assessed the effect of vitamin E on liver function and markers of fibrogenesis in patients with mild to moderate alcoholic hepatitis.
The team included 51 patients.
The patients received either 1000 I.U. of vitamin E or placebo for 3 months.
|Vitamin E did not decrease serum aminotransferases.|
|Journal of Hepatology|
The patients were followed for 1 year.
The researchers found that vitamin E did not decrease serum aminotransferases and serum bilirubin or increase in serum albumin.
In addition, prothrombin time did not change and serum creatinine remained in the normal range.
The team determined that monocyte nuclear factor-B binding activity decreased in patients who remained abstinent, regardless of whether they received vitamin E.
They found that serum hyaluronic acid decreased, while serum aminoterminal peptide of type III procollagen did not change.
Dr Esteban Mezey's team concluded, "Vitamin E treatment improves serum hyaluronic acid but has no beneficial effects on tests of liver function in patients with mild to moderate alcoholic hepatitis".