In this study, physicians from Korea and the United States investigated the effect of sildenafil on esophageal motor function in both healthy subjects and patients with nutcracker esophagus.
They included 8 healthy volunteers and 9 patients with nutcracker esophagus in the study.
Participants underwent esophageal manometries after either 20mL of distilled water or sildenafil (0.8 mg/kg) dissolved in 20mL of water was infused into the stomach.
The team assessed lower esophageal sphincter resting pressure, duration of lower esophageal sphincter relaxation, and the amplitudes of esophageal pressure waves before and after infusion.
|Sildenafil prolonged the duration of lower esophageal sphincter relaxation.|
|Neurogastroenterology and Motility|
The physicians found that sildenafil decreased the resting lower esophageal sphincter pressure. It also decreased the amplitude of peristaltic pressure waves at 3, 8 and 13 cm above the lower esophageal sphincter.
In addition, sildenafil prolonged the duration of lower esophageal sphincter relaxation.
However, the treatment had no effect on the velocity of peristalsis or the amplitude of peristaltic pressure waves 18 cm above the lower esophageal sphincter.
Dr Lee's team concluded, "Sildenafil may be considered as an alternative treatment in nutcracker esophagus although there are several limitations to be overcome".