In this study, a team of international physicians determined the rate of Helicobacter pylori reinfection versus recrudescence. They also identified possible risk factors for reinfection.
The team evaluated children and adults with upper GI symptoms who were treated at the Centro Médico Nacional Siglo XXI, Mexico.
They diagnosed H. pylori infection using urea breath test (UBT), histology, and culture.
All infected patients received triple therapy. Those who became UBT negative 4 to 6 weeks after treatment were considered as eradicated and were included in the study.
The physicians monitored a total of 141 patients for H. pylori recurrence 3, 6, 9, 12, 18, and 24 months.
In addition, the team isolated H. pylori from gastric biopsy samples before treatment. These isolate genotypes were compared with samples taken at recurrence.
During the study, recurrence occurred in 23% of patients.
|Recurrence occurred in 23% of patients.|
|American Journal of Gastroenterology|
However, in 28% of these recurrences H. pylori was eradicated spontaneously, indicating a transient reinfection.
The physicians determined that recurrence was greater in the subjects aged between 41 and 60 years.
The team also found that 75% of recurrence was true reinfection, while the rest was recrudescence.
Dr Yelda Leal-Herrera's team concluded, "In our population, recurrence rate is high in adults and transient reinfection is common".
"In several cases, reinfection occurred by multiple strains, which suggests that soon after eradication, patients are exposed to multiple sources of reinfection".