Osteopenia is common in patients with ulcerative colitis (UC), but less is known about fracture risk.
In this study, physicians from Rochester, Minnesota, examined the medical records of 273 patients with UC. The team looked for any evidence of fractures.
Patients were matched for age and gender with a control cohort.
The team estimated cumulative fracture incidence after diagnosis using the Kaplan-Meier method.
They also estimated the hazard ratio of fracture using Cox proportional hazards regression.
|Cumulative incidence of fracture:|
- patients = 40%
- controls = 42%
|Clinical Gastroenterology and Hepatology|
In this study, median follow-up was 13 years.
The physicians found that the cumulative incidence of any fracture from time of diagnosis was 40% at 25 years versus 42% in control subjects.
They also found that the hazard ratio, for cases versus controls, was 1.1 for any fracture and 1.3 for any osteoporotic fracture.
The team determined that other causes of secondary osteoporosis were associated with increased fracture risk. Estrogen use was protective.
Of the 273 cases, 38% had received corticosteroids, and 12% had taken them for 6 months or longer.
The physicians found that corticosteroids and bowel resection were not associated with fracture risk.
Dr Edward Loftus Jr's team concluded, "In this population-based cohort of patients with UC, fracture risk was not elevated relative to matched community control subjects".
"Use of corticosteroids did not appear to significantly influence the risk of fracture".