Propofol may be useful as a sedative during endoscopic procedures.
In this study, researchers from Indiana, USA, compared nurse-administered propofol with midazolam plus fentanyl for outpatient colonoscopy.
The team randomized 100 patients undergoing colonoscopy. Patients received either propofol, or midazolam plus fentanyl.
|Patients in the propofol group reached full recovery more quickly.|
|Clinical Gastroenterology and Hepatology|
All sedation was administered by a registered nurse and supervised by an endoscopist.
The researchers evaluated patient satisfaction, procedure and recovery times, neuropsychologic function, and complications.
The team found that the mean dose of propofol was 277 mg. The mean doses of midazolam and fentanyl were 7.2 mg and 117 µg, respectively.
They determined that the mean time to sedation was faster with propofol, and that the depth of sedation was significantly greater.
Furthermore, patients who received propofol reached full recovery more rapidly and were able to be discharged sooner.
The researchers also found that after recovery, patients in the propofol group scored better on tests reflective of learning, memory, working memory span, and mental speed.
Overall, there were 6 complications in the propofol group, and 5 in the midazolam and fentanyl group.
Patients in both groups reported similar levels of satisfaction.
Dr Brian Ulmera's team concluded, "Nurse-administered propofol resulted in several advantages for outpatient colonoscopy compared with midazolam plus fentanyl".