Identifying factors which increase the risk of acute pancreatitis is of considerable importance.
It is the most common and severe complication of endoscopic retrograde cholangiopancreatography (ERCP).
In this study, investigators from Italy aimed to identify the most important risk factors for post-ERCP pancreatitis.
The team performed a meta-analysis of 15 prospective clinical studies, which were selected from 52 reviewed articles.
|14 risk factors were identified.|
The team found that of the 14 risk factors identified, 5 were patient characteristics while 9 were related to endoscopic technique.
Patient-related risk factors included suspected sphincter of Oddi dysfunction (relative risk = 4.09), female gender (relative risk = 2.23), and previous pancreatitis (relative risk = 2.46).
Endoscopy-related factors included precut sphincterotomy (relative risk = 2.71), and pancreatic injection (relative risk = 2.2).
Dr Masci's team concluded, "This meta-analysis provides a clear basis for planning pharmacological studies or studies of new endoscopic techniques in patients at high risk of developing post-ERCP pancreatitis".
"Knowing which patients are most at risk may also make it easier to decide who should be considered unsuitable for same-day discharge".