Surgical resection is an important treatment for pulmonary metastases from colorectal carcinoma.
In this study, researchers from Germany analyzed the clinical course, outcome, and prognostic factors following this type of surgery.
|Overall 5-year survival = 32%.|
|Journal of Thoracic and Cardiovascular Surgery|
During the course of the study, 167 patients underwent complete pulmonary resection of metastatic colorectal carcinoma.
The research team included all patients who met the criteria for potentially curative operation.
They found that overall 5-year survival was 32%.
However, they determined that patients without lymph node involvement had longer survival, compared with patients with pulmonary and/or mediastinal lymph node metastases.
The researchers also found that the number of pulmonary metastases significantly influenced survival. Patients with a solitary metastasis had a 5-year survival of 45%, compared to 20% in patients with more 1 metastasis.
The team identified the prethoracotomy carcinoembryonic antigen serum level as an independent prognostic factor for survival. Patients who had a serum carcinoembryonic antigen level greater than 5ng/mL had a 5-year survival of 23%, while patients with normal levels had a 5-year survival of 48%.
Dr Joachim Pfannschmidt's team concluded, "Pulmonary resection of metastatic colorectal carcinoma is safe and results in long-term survival".
"Thoracic lymph node metastases, serum carcinoembryonic antigen level before metastasectomy, and the number of pulmonary metastases were identified as prognosis-related criteria for surgery".