The Chinese herbal supplements Chaso and Onshido are used for weight loss in Japan. However, the safety of these preparations is unknown.
In this study, published in the latest issue of the Annals of Internal Medicine, researchers describe patients who developed liver injury while taking Chaso or Onshido.
The team evaluated 6 patients who took Chaso and 6 patients who took Onshido before presenting with liver injury.
|Patients developed acute liver injury.|
|Annals of Internal Medicine|
They performed pathologic, clinical, and laboratory evaluations and chemical analysis of these herbal weight loss aids.
The investigators found that all 12 patients developed acute liver injury, which was characterized by a marked increase in serum liver chemistry values.
Furthermore, 2 patients developed fulminant hepatic failure. Of these, 1 patient required liver transplantation, and the other patient died.
The team determined that N-nitroso-fenfluramine, a variant of the appetite-depressant drug fenfluramine, was present in these products.
Dr Masayuki Adachi's team concluded, "The use of the weight loss aids Chaso and Onshido may be associated with acute liver injury".
"N-nitroso-fenfluramine is a possible hepatotoxic ingredient".