In this study, doctors from Nagasaki, Japan, analyzed the anti-HBs levels in 104 healthcare workers who received 3 booster HBV surface antigen (HBsAg) vaccines.
Booster vaccines were given because 80 workers became anti-HBs-negative a mean of 2.4 years after the primary vaccination. The remaining 24 had not responded to the primary vaccination.
The research team found that of the 104 workers in the study, 96% achieved seroprotection 1 month after booster vaccination.
|64% maintained anti-HBs levels after 10 years.|
They determined that although anti-HBs levels decreased as rapidly as those after primary vaccination, at 10 years post-booster 64% maintained anti-HBs levels of ≥ 10 mIU/ml.
Dr Kazuhiko Nakao's team concluded, "The additional 3-dose protocol of booster HBsAg vaccination is beneficial in maintaining a seroprotective level of anti-HBs until new immunogenic vaccination protocols are established".