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 21 February 2018

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News

Liver transplantation with hepatitis C virus-infected graft

No genetic recombination occurs among HCV quasispecies, or between donor and recipient HCV strains, in liver transplantation patients, finds a research team in the July issue of Hepatology.

News image

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A single host infected with differing viral strains provides an opportunity for studying host-virus and virus-virus interactions. These include viral interference, and genetic recombination, which are not able to be studied when a host is infected with a single viral strain.

Hepatitis C virus (HCV) is a positive single-strand RNA virus. It establishes persistent infection in up to 85% of infected individuals.

However, there is little data on the co-infection or super-infection of HCV.

In this study, researchers from the United States explored super-infection in liver transplantation patients, where both the recipient and donor were infected with different strains of HCV.

The team collected serial serum samples at multiple time points from 6 HCV-positive liver donor/recipient pairs.

Only 1 strain of HCV was identified at each time point in all 6 cases.
Hepatology

At each time point, they also determined the HCV genotype using restriction fragment length polymorphism analysis and phylogenetic analysis.

In addition, the researchers sequenced 3 full-length HCV isolates immediately after transplantation. These included both 5' and 3' ends.

The research team identified only 1 strain of HCV at each time point in all 6 cases.

They determined that recipient HCV strains took over in 3 cases, whereas donor HCV strains dominated after liver transplantation in the remaining 3 cases.

Dr Xiaofeng Fan's team concluded, "In all 6 cases studied, there was no genetic recombination detected among HCV quasispecies or between donor and recipient HCV strains".

Hepatology 2003; 38: 25-33
30 June 2003

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