Gastro-esophageal reflux is a public health concern which could have associated oesophageal complications, including adenocarcinoma, and possibly also head-and-neck and lung cancers.
Dr Eivind Ness-Jensen and colleagues from Stockholm, Sweden tested the hypothesis that reflux increases all-cause and cancer-specific mortalities in an unselected cohort.
The Nord-Trøndelag health study (HUNT), a Norwegian population-based cohort study, was used to identify individuals with and without reflux in 1995–1997 and 2006–2008, with follow-up until 2014.
All-cause and cancer-specific mortality were assessed from the Norwegian Cause of Death Registry and Cancer Registry.
The team included 4758 participants with severe reflux symptoms, and 51,381 participants without reflux symptoms, contributing 60,323 and 747,239 person-years at risk, respectively.
|For women, mortality was not increased with a mortality rate of 0.05 per 1000 person-years|
Severe reflux was not associated with all-cause mortality, overall cancer-specific mortality or mortality in cancer of the head-and-neck or lung.
The researchers observed a 6-fold increase in esophageal adenocarcinoma-specific mortality in men with severe reflux, with a mortality rate of 0.27 per 1000 person-years.
For women, the corresponding mortality was not significantly increased and the mortality rate was 0.05 per 1000 person-years.
Dr Ness-Jensen's team comments, "Individuals with severe reflux symptoms do not seem to have increased all-cause mortality or overall cancer-specific mortality."
"Although the absolute risk is small, individuals with severe reflux symptoms have a clearly increased esophageal adenocarcinoma-specific mortality."