Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 23 May 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Mobile infliximab dosing calculator for therapy optimization in IBD

February's issue of the Inflammatory Bowel Diseases investigates a mobile infliximab dosing calculator for therapy optimization in IBD.

News image

Inadequate infliximab drug exposure remains a clinical challenge and leads to high loss of response rates and therapy failure in inflammatory bowel disease (IBD).

Dr Travis Piester and colleagues determined the feasibility and pilot effectiveness of a novel, web-based, mobile infliximab dosing calculator for therapy optimization.

The researchers developed an mobile infliximab dosing calculator leveraging the known clinical variables of C-reative protein (CRP), albumin, patient’s weight, disease activity indices, calprotectin, drug trough levels, and antibodies to infliximab that significantly affect pharmacokinetics and/or outcomes.

A prospective observational cohort study in pediatric and young adult IBD patients receiving maintenance infliximab was performed.

System-wide practice adoption of mobile infliximab dosing calculator was achieved through a quality improvement (QI) initiative within a hospital-based infusion unit.

The team noted that 49 patients were followed over 9 months.

Infliximab trough goal of >5 μg/mL was achieved with 81% probability throughout the QI initiative
Inflammatory Bowel Diseases

Mobile infliximab dosing calculator recommendations for dose optimization were followed by the treating physicians in 89% of infusions.

The researchers noted that 13% of mobile infliximab dosing calculator recommendations were to escalate infliximab dosing.

The team noted that 54% of escalation recommendations were declined, and these patients were more likely to already be receiving infliximab dose intensification compared with those in whom escalation recommendations were followed.

From mobile infliximab dosing calculator initiation to end of follow-up, mean albumin levels remained unchanged at 3.8 g/dL.

The research team observed that the median CRP remained unchanged at 2 g/L.

Median calprotectin levels showed a downward trend from 30 to 27 μg/g.

The team found that the percentage of patients undergoing therapeutic drug monitoring in clinical care increased from 34% to 86% with the QI initiative.

The target median infliximab trough goal of >5 μg/mL was achieved with 81% probability throughout the QI initiative, an increase of 12% compared with pre-QI values.

Dr Piester's team concludes, "The use of a novel mobile infliximab dosing calculator is feasible and potentially effective, facilitating both standardization and individualization of therapy in clinical care."

"Mobile infliximab dosing calculator appears to be a practical infliximab dosing tool for point-of-care use, leveraging individual pharmacokinetic considerations."

Inflamm Bowel Dis 2018: 24(2): 227–234
29 January 2018

Go to top of page Email this page Email this page to a colleague

 23 May 2018 
Management of perianal fistulas in Crohn’s disease
 23 May 2018 
Cardiovascular risk in diabetes mellitus with NAFLD
 23 May 2018 
High body mass index is and ulcerative colitis
 22 May 2018 
Worldwide H.pylori prevalence
 22 May 2018 
PPI and risk of stroke
 22 May 2018 
Online tool predicts bowel dysfunction severity prior to anterior resection
 21 May 2018 
PPI use and cognitive decline
 21 May 2018 
Depressive symptoms in IBD youth
 21 May 2018 
Fecal incontinence and quality of life in IBD
 18 May 2018 
Esophageal dilatation in clinical practice 
 17 May 2018 
IBD and later extraintestinal manifestations
 17 May 2018 
Repeat stool DNA testing
 17 May 2018 
IBS and chronic fatigue following GI infection
 16 May 2018 
Factors associated with fecal incontinence
 16 May 2018 
Diagnostic delay in Crohn's disease
 16 May 2018 
Cardiovascular risk in diabetes mellitus with NAFLD
 15 May 2018 
Guidelines for management of Crohn's
 15 May 2018 
New therapies for CDI
 15 May 2018 
Hep B in the Grey Zone
 14 May 2018 
Blood test for the diagnosis of fibrotic NASH
 14 May 2018 
Outcomes at bariatric centers of excellence
 14 May 2018 
Management of perianal fistulas in Crohn’s
 11 May 2018 
Detection of undiagnosed celiac disease
 11 May 2018 
Alcohol consumption and drug-induced liver injury
 10 May 2018 
Colorectal cancer screening
 10 May 2018 
Post‐operative complications in elderly IBD
 10 May 2018 
Fibrosis in patients with chronic hepatitis B
 09 May 2018 
Esophageal dilatation in clinical practice 
 09 May 2018 
Fecal incontinence
 09 May 2018 
Health problems and IBS
 07 May 2018 
Health problems and IBS
 07 May 2018 
Assessment of diminutive colorectal polyps
 07 May 2018 
Omitting antibiotics in uncomplicated acute diverticulitis
 04 May 2018 
National Institutes of Health workshop and obesity
 04 May 2018 
Factors associated with fecal incontinence
 04 May 2018 
Colorectal cancer screening and ethnic inequities
 03 May 2018 
Gastrointestinal ultrasound in IBD
 03 May 2018 
Ultransonography in postsurgical recurrence in Crohn's
 02 May 2018 
Symptom assessment in cirrhotic ascites
 02 May 2018 
Hep C antiviral treatment and liver cancer risk
 02 May 2018 
Chronic Hep B
 01 May 2018 
European guidelines on pancreatic cystic neoplasms
 01 May 2018 
Interferon‐free regimens in Hep C
 01 May 2018 
Age at IBD onset and extraintestinal complications
 30 April 2018 
Formula for preterm infants
 30 April 2018 
Primary antibiotic resistance and sequential therapy for H. pylori
 30 April 2018 
Patient-reported outcome measures in IBD trials
 27 April 2018 
Anxiety scale for chronic esophageal disease
 27 April 2018 
Disease activity in eosinophilic esophagitis
 27 April 2018 
Eastern and western practices for endoscopic resection of colorectal lesions
 26 April 2018 
Obesity and physical activity in diverticulosis
 26 April 2018 
Primary sclerosing cholangitis in the USA
 25 April 2018 
Central mediators of irinotecan-induced steatohepatitis
 25 April 2018 
Aspirin and pancreatic cancer
 25 April 2018 
Neuroimaging in Hep C
 24 April 2018 
Scoring system identifies cancer risk in Barrett's
 24 April 2018 
Microbiome in athletes vs sedentary subjects
 23 April 2018 
Genome-wide study on HBV-related acute-on-chronic liver failure
 23 April 2018 
Antibody suitable for further clinical development to complement existing therapeutic strategies for HCV
 23 April 2018 
Sleep deprivation and NAFLD in the USA

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us