Current healthcare systems do not effectively promote weight reduction in patients with obesity and gastroesophageal reflux disease (GERD).
The Reflux Improvement and Monitoring (TRIM) program provides personalized, multidisciplinary, health education and monitoring over 6 months.
Dr Rena Yadlapati and colleagues from Colorado, USA measured the effectiveness of TRIM on GERD symptoms, quality of life, and weight, and examined patient health beliefs related to TRIM.
This prospective mixed methods feasibility study was performed at a single center between 2015 and 2017, and included adult patients with GERD and a body mass index ≥30 kg/m2.
|Among the +TRIM cohort, the mean baseline GerdQ scores decreased at 3 months|
|American journal of Gastroenterology|
Quantitative analysis consisted of a pre- to post-intervention analysis of TRIM participants (+TRIM Cohort), and a multivariable longitudinal mixed model analysis of +TRIM vs. patients who declined TRIM (−TRIM Cohort).
The team's primary outcomes were change in patient-reported GERD symptom severity (GerdQ) and quality of life (GerdQ-DI), and change in percent excess body weight (%EBW).
Qualitative analysis was based on 2 focus groups of TRIM participants.
Among the +TRIM cohort, the team found that mean baseline GerdQ scores decreased at 3 months, and 6 months.
The researchers noted that mean GerdQ-DI scores decreased, but did not reach statistical significance.
Compared with the −TRIM cohort, the team observed that the reduction in %EBW was significantly greater at 3, 6, and 12 months among the +TRIM cohort.
In qualitative analysis, the researchers found that patients unanimously appreciated the multidisciplinary approach and utilized weight loss effectively to improve GERD symptoms.
Dr Yadlapati's team concludes, "In this mixed methods feasibility study, participation in TRIM was associated with symptom improvement, weight reduction, and patient engagement."