Colorectal cancer leads to significant morbidity/mortality worldwide.
Defining critical research gaps, their prioritization and resolution, could improve patient outcomes.
Dr Mark Lawler and colleagues evaluated a multidisciplinary panel of patients, clinicians and researchers.
The team constituted 8 working groups including discovery science, risk, prevention, early diagnosis and screening, pathology, curative treatment, stage IV disease, and living with and beyond colorectal cancer.
A series of discussions led to development of draft papers by each working group, which were evaluated by a 20-strong patient panel.
|15 critical research gaps are summarized|
A final list of research gaps and research recommendations was endorsed by all participants.
The research team summarized 15 critical research gaps, rangind from lack of realistic models that recapitulate tumor/tumor micro/macroenvironment, insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to colorectal cancer risk, to Lack of effective communication between relevant stakeholders.
Dr Lawler's team concludes, "Prioritizing research activity and funding could have a significant impact on reducing colorectal cancer disease burden over the next 5 years."