Little is known about the epidemiology of sessile serrated polyps.
Dr Sonnenberg and colleagues from Oregon, USA investigated the influence of Helicobacter pylori gastritis and patient demographic characteristics on the prevalence of sessile serrated polyps using a large national database of patients undergoing bi-directional endoscopy.
De-identified patient data were extracted from the Miraca Life Sciences electronic database of histopathological reports.
The total study population comprized 228,506 subjects, of whom 28,890 carried a diagnosis of Helicobacter pylori gastritis, and 11,285 sessile serrated polyps.
|The prevalence of sessile serrated polyps within the USA is characterized by a marked ethnic variation |
The researchers found that age, female gender, and Helicobacter pylori gastritis exerted the strongest influence on the occurrence of sessile serrated polyps.
In comparison with the population comprizing Caucasians and African Americans, sessile serrated polyps were less common among subjects of Hispanic, East Asian, Indian or Middle Eastern descent.
The team noted that all these ethnic subgroups were also characterized by a higher prevalence of Helicobacter pylori than the comparison group.
A low prevalence of Helicobacter pylori was significantly associated with a high prevalence of sessile serrated polyps.
Dr Sonnenberg's team comments, "The prevalence of sessile serrated polyps within the United States is characterized by a marked ethnic variation."
"The inverse correlation between the prevalence of Helicobacter pylori, and sessile serrated polyps suggests that gastric infection with Helicobacter pylori may be partly responsible for the observed ethnic distribution of sessile serrated polyps."