The application of complete mesocolic excision in colon cancer is controversial.
Dr Ye and colleagues performed a meta-analysis to compare the safety, quality and effect of complete mesocolic excision with non-complete mesocolic excision in patients with colon cancer.
The team searched PubMed, ScienceDirect, the Cochrane Library and Scopus to identify studies comparing complete mesocolic excision with non-complete mesocolic excision in colon cancer.
|Complete mesocolic excision also had positive effects on 5-year survival|
The research team focused on 3 study outcome areas including safety, quality, and effect.
A total of 8586 patients from 12 studies were included in the meta-analysis.
Complete mesocolic excision was associated with greater intra-operative blood loss, more postoperative surgical complications, longer large bowel resection, greater distance from the tumor to the high vascular tie, larger area of mesentery, and more lymph nodes than non-complete mesocolic excision.
Complete mesocolic excision also had positive effects on 5-year survival, 3-year survival, and 3-year survival for Stage III disease compared with non-complete mesocolic excision.
Dr Ye's team concludes, "Limited evidence suggests that complete mesocolic excision is a more effective strategy for improving specimen quality and survival but with a higher complication rate."