Hepatitis E virus (HEV) infection appears to be more common than previously thought.
HEV seroprevalence in patients on maintenance hemodialysis is unclear with a range from 0% to 44%.
In addition, risk factors of transmission of HEV in patients on hemodialysis are unknown.
Dr Bazerbachi and colleagues from Minnesota, USA performed a systematic review and meta-analysis of HEV seroprevalence in hemodialysis patients compared with controls.
The team performed a systematic search of several databases identified all observational studies with comparative arms.
|31 studies were identified from 17 countries between 1994 and 2016|
|Alimentary Pharmacology & Therapeutics|
There were 2 reviewers extracted data and assessed the methodological quality.
The researchers identified 31 studies from 17 countries between 1994 and 2016.
The team identified 16 studies that had adequate quality, and 15 that had moderate limitations.
HEV infection was more prevalent in patients on hemodialysis compared with controls.
The researchers conducted several subgroup analyses without difference in results.
Specific risk factors of HEV transmission in patients on hemodialysis were not clearly identified.
Dr Bazerbachi's team concludes, "Hepatitis E virus infection is more prevalent in patients on hemodialysis compared with non-hemodialysis control groups."
"Further studies are needed to determine risk factors of acquisition, impact on health, and risk for chronic HEV especially among those patients going to receive organ transplantation."