Pouch surgery, a common intervention for ulcerative colitis complications, is often associated with the development of pouchitis.
Dr Dotan and colleagues identified predictors of pouch outcome in a cohort of patients with ulcerative colitis.
The researchers conducted a retrospective unmatched case-cohort study in a tertiary IBD referral center.
Adult patients with ulcerative colitis were classified into the worst phenotype throughout follow-up, including normal pouch, a form of chronic pouchitis, or episodic recurrent acute pouchitis.
Risk factors for pouchitis were detected using statistical models.
|Median survival for sustained normal pouch was 11 years|
|Alimentary Pharmacology & Therapeutics|
The research team followed up 253 pouch patients for 14 years.
Only 28% patients maintained a favorable outcome of a sustained normal pouch.
The researchers found that these patients were older at ulcerative colitis diagnosis, had longer ulcerative colitis duration until surgery, and had higher rates of referral to surgery due to nonrefractory complications compared with pouchitis patients.
Median survival for sustained normal pouch was 11 years, and it was longer in the nonrefractory group.
Dr Dotan's team comments, "Most patients with ulcerative colitis undergoing pouch surgery will develop pouchitis."
"Patients operated for nonrefractory indications have a more favorable outcome."
"These results may contribute to pre- and post-surgical decision-making."
"The findings imply that the processes determining UC severity may be similar to that causing pouchitis."