Nonalcoholic fatty liver disease (NAFLD) results from excessive fat accumulation in the liver in the absence of excessive alcohol consumption.
Insulin resistance (IR) is proposed to be an underlying pathogenic factor in the development and progression of disease.
There are currently no proven pharmacotherapies and weight loss is the only prescribed treatment despite a lack of evidence to support a specific diet or lifestyle therapy.
Dr Audrey Tierney and colleagues reviewed is to evaluate the efficacy of dietary lifestyle interventions on IR measured by Homeostasis model assessment in patients with NAFLD.
|3 studies that involved dietary interventions|
|European Journal of Gastroenterology|
A systematic electronic search of Medline, Scopus, The Cochrane Library, CINAHL and PubMed databases was performed by two independent reviewers.
Randomized control trials evaluating the efficacy of diet and lifestyle interventions on IR in adults diagnosed with NAFLD were included.
The team identified a total of 6441 articles, of which 8 randomized control trials fulfilled the inclusion criteria.
There were 3 studies that involved dietary interventions, and 5 incorporated diet and exercise.
The majority of intervention groups resulted in significant reductions in IR, with no significant changes observed in the control groups.
Lifestyle interventions compared with controls reduced IR measured by homeostasis model assessment.
Dr Tierney's team comments, "All diet and diet and lifestyle intervention trials were efficient in reducing IR in participants with NAFLD."
"A lack of literature and variation across interventions warrants the need for extensive research to establish firm dietary lifestyle recommendations."