Patients with functional GI disorders are commonplace in the gastroenterologist's practice.
A number of these patients may be refractory to peripherally acting agents, yet respond to central neuromodulators.
Dr Harley Sobin and colleagues from North Carolina, USA outline the mechanisms by which they work, the differences between classes and individual agents, and the various adverse effects.
|These agents can benefit mood,and pain|
|American Journal of Gastroenterology|
The team report that there are benefits and potential adverse effects to using TCAs, SSRIs, SNRIs, atypical antipsychotics, and miscellaneous central neuromodulators in these patients.
These agents can benefit mood, pain, diarrhea, constipation, nausea, sleep, and depression.
Dr Sobin's colleagues comment, "Dosing, augmentation strategies, and treatment scenarios specifically for painful functional GI disorders, and chronic nausea and vomiting syndrome are outlined."