Although abdominal visceral fat has been associated with erosive esophagitis in cross-sectional studies, there are no data that describe its longitudinal effects.
Dr Su Youn Nam evaluated the longitudinal effects of abdominal visceral fat on the development of new erosive esophagitis in patients who did not have erosive esophagitis at baseline.
The researchers performed a single-center prospective study.
A total of 1503 participants without erosive esophagitis at baseline were followed up for 34 months, and they underwent esophagogastroduodenoscopy and computed tomography at both baseline and during follow-up.
The longitudinal effects of abdominal visceral fat on the development of new erosive esophagitis were evaluated.
|New erosive esophagitis was inversely related to the follow-up Helicobacter pylori status|
|European Journal of Gastroenterology & Hepatology|
The research team found that new esophagitis developed in 83 patients.
Compared with the first quartile, the third, and the fourth of baseline visceral fat quartiles, the third and the fourth follow-up visceral fat quartiles, and the fourth visceral fat change quartile were associated with increased development of new erosive esophagitis.
The researchers found that new erosive esophagitis was inversely related to the follow-up Helicobacter pylori status.
The team noted that it was associated positively with the presence of a hiatal hernia and smoking during follow-up, but it was not associated with reflux symptoms, the H. pylori status, presence of a hiatal hernia or smoking at baseline.
Dr Gould's team concludes, "Higher level of visceral fat at baseline and follow-up visceral fat, and greater changes in the visceral level were associated linearly with the development of new erosive esophagitis in this longitudinal study."