The global burden of colorectal cancer is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030.
In this study, Dr Melina Arnold and colleagues from France described the recent colorectal cancer incidence and mortality patterns and trends linking the findings to the prospects of reducing the burden through cancer prevention and care.
Estimates of sex-specific colorectal cancer incidence and mortality rates in 2012 were extracted from the GLOBOCAN database.
|Colorectal cancer incidence and mortality rates vary up to 10-fold worldwide|
Temporal patterns were assessed for 37 countries using data from Cancer Incidence in Five Continents (CI5) volumes I–X and the WHO mortality database.
Trends were assessed via the annual percentage change using joinpoint regression, and discussed in relation to human development levels.
The team reported that colorectal cancer incidence and mortality rates vary up to 10-fold worldwide, with distinct gradients across human development levels, pointing towards widening disparities and an increasing burden in countries in transition.
Generally, the researchers found that colorectal cancer incidence and mortality rates are still rising rapidly in many low-income and middle-income countries.
The research team noted stabilizing or decreasing trends in highly developed countries where rates remain among the highest in the world.
Dr Arnold's team commented, "Patterns and trends in colorectal cancer incidence, and mortality correlate with present human development levels and their incremental changes might reflect the adoption of more western lifestyles."
"Targeted resource-dependent interventions, including primary prevention in low-income, supplemented with early detection in high-income settings, are needed to reduce the number of patients with colorectal cancer in future decades."