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 25 May 2018

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News

Mesenchymal stromal cells for fistula treatment of Crohn’s disease

The latest issue of the Digestive Diseases & Sciences examines the efficacy of mesenchymal stromal cells for fistula treatment of Crohn’s disease.

News image

The introduction of mesenchymal stromal cells has changed the management of Crohn’s fistula, while it remains controversial. 

Dr Lin and colleagues provided an overview of efficacy and optimum state of mesenchymal stromal cells treatment on Crohn’s fistula.

Studies reporting mesenchymal stromal cells treatment on Crohn’s fistula were searched and included. 

A fixed-effects model was used to assess the efficacy of mesenchymal stromal cells, and outcomes of healing and recurrence were used to evaluate the best states of mesenchymal stromal cells intervention.

The team enrolled 14 articles. 

A moderate dose mesenchymal stromal cells had a higher healing rate
Digestive Diseases & Sciences
The research team showed mesenchymal stromal cells had a significant efficacy compared to other treatments. 

Notably, after mesenchymal stromal cells treatment, the group of Crohn’s disease activity index (CDAI) baseline >150 group had a higher healing rate, and a clinical response compared to CDAI baseline of <150. 

The research team found that the duration time of Crohn’s disease, and fistulas had a negative correlation with healing rate accompanied by mesenchymal stromal cells therapy. 

Then, a moderate dose mesenchymal stromal cells had a higher healing rate, and lower recurrence rate compared to other dosages. 

Moreover, the team noted that adipose-derived mesenchymal stromal cells therapy had an advantage over bone marrow-derived mesenchymal stromal cells in terms of low relative risk.

Dr Lin's team comments, "The evidence supported the effect of mesenchymal stromal cells at a more appropriate time of Crohn’s fistula."

"CDAI baseline has been a candidate for evaluating effectiveness of mesenchymal stromal cells application on Crohn’s fistula."

Dig Dis Sci 2017: 62(4): 851–860
20 March 2017

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