Fecal microbiota transplantation is an important therapeutic option for Clostridium difficile infection.
Promising findings suggest that fecal microbiota transplantation may play a role also in the management of other disorders associated with the alteration of gut microbiota.
Although the health community is assessing fecal microbiota transplantation with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardized treatment into the clinical practice with safety and proper governance.
Dr Giovanni Cammarota and colleagues from Italy provided an evidence-based recommendation to drive the practical implementation of fecal microbiota transplantation.
|28 experts from 10 countries collaborated|
In this European Consensus Conference, 28 experts from 10 countries collaborated, in separate working groups and through an evidence-based process, to provide statements on the following key issues, including fecal microbiota transplantation indications; donor selection; preparation of fecal material; clinical management and fecal delivery and basic requirements for implementing an fecal microbiota transplantation center.
The research team evaluated statements developed by each working group, and voted by all members, first through an electronic Delphi process, and then in a plenary consensus conference.
The team released recommendations according to best available evidence, in order to act as guidance for physicians who plan to implement fecal microbiota transplantation, aiming at supporting the broad availability of the procedure, discussing other issues relevant to fecal microbiota transplantation, and promoting future clinical research in the area of gut microbiota manipulation.
Dr Cammarota's team concluded, "This consensus report strongly recommends the implementation of fecal microbiota transplantation centers for the treatment of Clostridium difficile infection as well as traces the guidelines of technicality, regulatory, administrative and laboratory requirements."