Fat intake is generally thought as a risk factor for onset of ulcerative colitis (UC), while epidemiological data had been controversial.
Dr Jin Li and colleagues from China evaluated the role of fat intake in the development of UC.
Comprehensive search in PubMed and Embase was conducted to identify all relevant studies, and the role of fat intake in the development of UC was quantitatively assessed by dose–response meta-analysis.
The team found that 9 studies were indentified with a total of 966 UC cases and 171,589 controls.
|The summary relative risks for per 30 gram increment/day were 1.023 for total fat intake|
|Journal of Gastroenterology & Hepatology|
The researchers observed no evidence of a nonlinear dose–response association between fat intake and UC risk.
Overall, the summary relative risks for per 30 gram increment/day were 1.023 for total fat intake, 1.063 for saturated fat intake, 1.214 for monounsaturated fat intake, and 1.247 for polyunsaturated fat intake, respectively.
The research team showed inconsistent results on polyunsaturated fat intake, which was significantly related with UC risk after adjusting for smoking.
For polyunsaturated fat and monounsaturated fat subtypes, no subtypes were significantly associated with UC risk, and only docosahexaenoic acid showed a potential protective effect in the development of UC.
Dr Li's team comments, "This meta-analysis suggested a lack of association between fat intake and UC risk, and large-scale prospective designed studies are warranted to confirm our findings."