Previous studies have shown a close relationship between Helicobacter pylori, insulin resistance, and altered metabolic parameters.
However, the effects of Helicobacter pylori eradication on these conditions remain controversial.
Dr Sikarin Upala and colleagues carried out a systematic review and meta-analysis to evaluate the effects of Helicobacter pylori eradication on insulin resistance and metabolic parameters.
The team searched CENTRAL, MEDLINE, and EMBASE databases from their inception to 2016.
|There was no difference in HOMA-IR after Helicobacter pylori eradication|
|European Journal of Gastroenterology & Hepatology|
Insulin resistance (HOMA-IR), body weight (BW), BMI, waist circumference, triglycerides (TG), high-density and low-density lipoprotein-cholesterol (HDL-C and LDL-C), and fasting blood glucose (FBG) were compared between patients with and without Helicobacter pylori eradication.
The team evaluated 5 studies, and showed no difference in HOMA-IR after Helicobacter pylori eradication.
The researchers observed that eradication significantly increased BMI, and BW, but had no significant effects on TG, LDL-C, HDL-C, or FBG.
Dr Upala's team concludes, "Helicobacter pylori eradication does not improve insulin resistance, TG, HDL-C, LDL-C, or FBG, but may increase BW and BMI."
"Further studies are needed to clarify the effect of Helicobacter pylori eradication on metabolism."