Sex and sex hormones can affect responses of patients with nonalcoholic fatty liver disease (NAFLD) to metabolic stress, and development of hepatocyte injury and inflammation.
Dr Ayako Suzuki and colleagues from North Carolina, USA collected data from 3 large U.S. studies of patients with NAFLD to assess the association between histologic severity and sex, menopause status, synthetic hormone use, and menstrual abnormalities in 1112 patients with a histologic diagnosis of NAFLD.
The researchers performed logistic or ordinal logistic regression models, adjusting for covariates relevant to an increase of hepatic metabolic stress.
|Use of oral contraceptives was associated with an increased risk of lobular inflammation|
|Clinical Gastroenterology & Hepatology|
The research team found that premenopausal women were at an increased risk of lobular inflammation, hepatocyte ballooning, and Mallory-Denk bodies than men and also at an increased risk of lobular inflammation, and Mallory-Denk bodies than postmenopausal women.
The team observed that use of oral contraceptives was associated with an increased risk of lobular inflammation and Mallory-Denk bodies in premenopausal women, whereas hormone replacement therapy was associated with an increased risk of lobular inflammation in postmenopausal women.
Dr Suzuki's team concludes, "Being a premenopausal woman or a female user of synthetic hormones is associated with increased histologic severity of hepatocyte injury, and inflammation among patients with NAFLD at given levels of hepatic metabolic stress."