Although the Geboes score and modified Riley score are commonly used to evaluate histological disease activity in UC, their operating properties are unknown.
Dr Barrett Levesque and colleagues from Canada, USA developed an alternative instrument.
There were 4 pathologists that scored 48 ulcerative colitis colon biopsies using the Geboes score, modified Riley score, and a visual analogue scale global rating.
Intra-rater and inter-rater reliability for each index and individual index items were measured using intraclass correlation coefficients.
|Items with high reliability were used to develop the Robarts histopathology index|
Items with high reliability were used to develop the Robarts histopathology index.
The research team found that the inter-rater intraclass correlation coefficients for the total Geboes score and modified Riley scores were 0.79, and 0.80.
The correlation estimates between change scores in Robarts histopathology index and change score in Geboes score and modified Riley score were 0.75 and 0.84, respectively.
The researchers found that the standardized effect size and Guyatt's responsiveness statistic estimates for Geboes score, modified Riley score and Robarts histopathology index were 1.87 and 1.23, 1.29 and 0.88, and 1.05 and 0.88, respectively.
Dr Levesque's team concludes, "The Robarts histopathology index is a new histopathological index with favorable operating properties."