Drug-induced autoimmune hepatitis is a controversial and poorly characterized phenotype of drug-induced liver injury.
Dr Raúl Andrade and colleagues from Spain evaluated drug-induced liver injury with autoimmune features.
Studies have tried to further characterize drug-induced liver injury cases with autoimmune features attributed to nitrofurantoin minocycline, methyldopa, and hydralazine in the drug-induced liver injury database.
|Drug-induced liver injury cases with autoimmune features were attributed to methyldopa|
|Clinical Gastroenterology & Hepatology|
The team reported that those with available DNA were genotyped to compare the allele frequencies of the commonest idiopathic autoimmune hepatitis risk alleles HLA-DRB1*03:01 and DRB1*04:01 in whites.
Dr Andrade's team concludes, "Neither the cohort considered as a whole compared with a control population, nor the subanalysis in patients with autoimmune features, were associated with these HLA class II risk alleles."