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 21 February 2018

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News

Esophageal eosinophilia is inversely associated with H pylori

A study in November's Gastroenterology finds an inverse association of esophageal eosinophilia with H pylori based on analysis of a US pathology database.

News image

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Eosinophilic esophagitis is of increasing prevalence and believed to result from allergic processes.

Helicobacter pylori has been inversely associated with allergic diseases, but there is no known relationship between H pylori, eosinophilic esophagitis, and esophageal eosinophilia.

Dr Evan Dellon and colleagues from North Carolina, USA investigated the association between esophageal eosinophilia and H pylori infection.

Subjects reported symptom episodes 34% of the time
Gastroenterology

The research team performed a cross-sectional study of data, collected from a US pathology database, on 165,017 patients in the United States who underwent esophageal and gastric biopsies from 2008 through 2010.

Patients with and without H pylori on gastric biopsy were compared, and odds of esophageal eosinophilia were determined.

From the data analyzed, the team found that 34% had normal esophageal biopsy specimens, 4% had esophageal eosinophilia, and 7% had H pylori infection.

Esophageal eosinophilia was inversely associated with H pylori.

Compared with patients with normal esophageal biopsy specimens, odds of H pylori were reduced among patients with 15 or more eosinophils per high-power field (eos/hpf), 45 or more eos/hpf, 75 or more eos/hpf, and 90 or more eos/hpf.

The researchers observed a similar dose-response trend for increasing clinical suspicion for eosinophilic esophagitis and decreasing prevalence of H pylori.

In addition, severity of histologic effects of H pylori was inversely associated with esophageal eosinophilia.

All trends held in multivariate analysis.

Dr Dellon's team commented, "In a large cross-sectional analysis, H pylori infection was inversely associated with esophageal eosinophilia."

"This relationship could have implications for the pathogenesis and epidemiology of eosinophilic esophagitis."

Gastroenterol 2011: 141(5): 1586-1592
25 October 2011

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