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 27 May 2018

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News

Heliocobacter pylori infection impairs drug absorption

The latest publication of the Alimentary Pharmacology & Therapeutics systematically reviews Heliocobacter pylori infection and impaired drug absorption.

News image

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Impaired acid secretion may affect drug absorption and may be consequent to corporal H pylori-gastritis, which may affect the absorption of orally administered drugs.

Professor Annibale and colleagues from Italy focused on the evidence of impaired drug absorption associated with H pylori infection.

The researchers systematically searched MEDLINE/EMBASE/SCOPUS databases up to 2008 for English articles.

The research team used keywords including drug malabsorption/absorption, stomach, H pylori, gastritis, gastric acid, gastric pH, hypochlorhydria, gastric hypoacidity.

Study selection was made from 2099 retrieved articles, of which 5 studies were identified as relevant.

In H pylori-subjects, delavirdine absorption increased by 150% after eradication
Alimentary Pharmacology & Therapeutics

The researchers extracted data on investigated drugs, study type, main features of subjects, study design, intervention type and results.

In all, 5 studies investigated impaired absorption of l-dopa, thyroxine and delavirdine in H pylori infection.

The researchers observed that eradication treatment led to a 21% to 54% increase in l-dopa in Parkinon's disease.

Thyroxine requirement was higher in hypochlorhydric goitre with H pylori-gastritis and thyrotropin levels decreased by 94% after treatment.

In H pylori- and HIV-positive hypochlorhydric subjects, delavirdine absorption increased by 57% with orange juice administration, and by 150% after eradication.

Dr Annibale’s team commented, “A plausible mechanism of impaired drug absorption is decreased acid secretion in H pylori-gastritis patients.”

H pylori infection and hypochlorhydria should be considered in prescribing drugs the absorption of which is potentially affected by intragastric pH.”

Aliment Pharmacol Ther 2008: 29(4): 379-86


26 January 2009

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